Software Engineering Radio is produced by a bunch of german software engineers, among them Markus Völter. This is from professional engineers for professional engineers.
Ruby on Rails Podcast is for all those who develop Web-based software in Ruby. The experts you can hear are THE top experts in the field.
Security Now! with Leo Laporte and Stephen Gibson. If you are interested in every detail about security issues subscribe to this podcast. This podcast teaches all the important stuff. Absolutely entertaining.
This Week in Tech by Leo Laporte really rocks. It is NOT about software but about IT news in general. Very entertaining. Hear this if you are a real geek.
Scientific American. Normally not about Software Engineering, to be honest. But I must admit that science is another favourite of mine.
What about you? Do you also listen to podcasts? Any programming or architecture related podcast I forgot to mention? I'd be delighted to receive some pointers to other interesting stuff.